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Deaths due to this cause: 68,968

Deaths per 100,000 people: 1.3

Percent of total deaths: 0.15%

Cause is most prevalent in: District of Columbia (2.44 deaths per 100,000 people)

Diabetes mellitus causes people to produce either insufficient levels of insulin, or insulin that does not function as it’s supposed to—ultimately resulting in an . The disease has the capacity to be lethal in a handful of ways, one of which is creating multiple roadblocks in the way of one’s circulatory functioning.

Deaths due to this cause: 71,088

Deaths per 100,000 people: 1.3

Percent of total deaths: 0.16%

Cause is most prevalent in: District of Columbia (5.05 deaths per 100,000 people)

While the debate over marijuana legalization rages on, many proponents point to the fact alcohol is an  substance that remains legal. While alcohol is more commonly thought of as dangerous in the contexts of driving and misconduct, it also creates a plethora of long-term consequences, including exacerbation of disorders such as .

Deaths due to this cause: 72,190

Deaths per 100,000 people: 1.3

Percent of total deaths: 0.16%

Cause is most prevalent in: Mississippi (1.99 deaths per 100,000 people)

Though tumors are typically associated with cancer, they . Malignant neoplasms, however, refer to tumors that carry the deadly disease and can be found in a handful of locations throughout the body. Cervical cancer is one of the more easily treatable variations of the tissue-destroying disease, and in many cases, can be avoided altogether via the use of . Unfortunately, the statistics prove it still remains a frequent cause of death.

Deaths due to this cause: 76,893

Deaths per 100,000 people: 1.4

Percent of total deaths: 0.17%

Cause is most prevalent in: Rhode Island (2.13 deaths per 100,000 people)

While cancer originating in the bile duct is rare in general, intrahepatic (liver-originating) bile duct cancer is . Though it can be difficult to detect, this form of carcinoma is typified by patients experiencing . 

Deaths due to this cause: 77,889

Deaths per 100,000 people: 1.4

Percent of total deaths: 0.17%

Cause is most prevalent in: Alaska (Unreliable deaths per 100,000 people)

Amongst the most difficult situations a parent can be confronted with is how to appropriately care for a child with a severe developmental disorder. The most well-known of these include autism, Asperger syndrome, and Tourette's. Though the  young children can face in their early growth stages grows longer, new medical discoveries are made every year.

Deaths due to this cause: 78,191

Deaths per 100,000 people: 1.4

Percent of total deaths: 0.17%

Cause is most prevalent in: Hawaii (Unreliable deaths per 100,000 people)

Though Hawaii is typically thought of as one of the happiest places on Earth, the statistics reveal a darker truth—the state leads in suicide by handgun. According to a study conducted by the Hawaiian government, the majority of these stemmed either from  of some sort.
 

Deaths due to this cause: 78,726

Deaths per 100,000 people: 1.4

Percent of total deaths: 0.18%

Cause is most prevalent in: District of Columbia (2.34 deaths per 100,000 people)

Uterine malignancies are representative of a  of cancers from which women suffer, and while there are a few variations, endometrial carcinomas account for more than 9 in 10 cases. The majority of these instances are considered Type I endometrial carcinomas, which are most common in women 55 to 65 years old, while cases of Type II are far rarer and primarily seen in women between 65 and 75 years old.

Deaths due to this cause: 78,845

Deaths per 100,000 people: 1.5

Percent of total deaths: 0.18%

Cause is most prevalent in: South Dakota (2.69 deaths per 100,000 people)

Intestinal obstruction refers to the instance of food being unable to pass through one’s small intestine or large intestine. While it can be treated when caught, symptoms can often be difficult to notice.  are all sensations that can be misconstrued for something less serious, so it’s advised that patients experiencing those get checked regardless so as to avoid a worst-case scenario.

Deaths due to this cause: 80,002

Deaths per 100,000 people: 1.5

Percent of total deaths: 0.18%

Cause is most prevalent in: Iowa (2.3 deaths per 100,000 people)

Also known as CLL for short, chronic lymphocytic leukaemia is a type of cancer where an excess of weak white blood cells are formed in one’s bone marrow. Though the weaker cells are not intrinsically harmful to the body, their unwanted presence  of properly functioning white and red blood cells, as well as platelets—each of which serve to fight off various infections.
 

Deaths due to this cause: 80,416

Deaths per 100,000 people: 1.5

Percent of total deaths: 0.18%

Cause is most prevalent in: Arkansas (2.71 deaths per 100,000 people)

Though many of the cancers on this list are associated with a clearly defined origin, there are a fair deal whose primary location is unknown for one reason or another. In cases like this, the malignant neoplasm is said to be spread, indicating a cancer that has moved throughout the body to the point that its original location is undetectable. 

Deaths due to this cause: 82,031

Deaths per 100,000 people: 1.5

Percent of total deaths: 0.18%

Cause is most prevalent in: Hawaii (2.98 deaths per 100,000 people)

A heart disease that is , dilated cardiomyopathy usually begins in the left ventricle, causing the muscle to become stretchy and thin—resulting in difficulty breathing and swelling of various joints in many cases. Studies have shown that DCM often stems from poor health habits such as excessive alcohol consumption or poor diet.

Deaths due to this cause: 82,968

Deaths per 100,000 people: 1.5

Percent of total deaths: 0.18%

Cause is most prevalent in: District of Columbia (3.44 deaths per 100,000 people)

Hepatitis refers to an inflammation of the liver, and the three variations of the disease are each assigned their own letter to distinguish the varying causes and severities. Hepatitis C can be labeled —indicative of a short-term infection which people typically overcome, or , indicating a serious liver problem that could lead to scarring and the development of cancer.

Deaths due to this cause: 87,087

Deaths per 100,000 people: 1.6

Percent of total deaths: 0.19%

Cause is most prevalent in: Florida (10.65 deaths per 100,000 people)

Though dementia disorders such as Alzheimer’s do not intrinsically kill people, declining brain function ultimately plays a direct role in the passing of older individuals. People with Alzheimer’s, however, have been dying at an alarmingly faster rate in recent years; the mortality rate of affected individuals  between 1999 and 2014.

Deaths due to this cause: 88,611

Deaths per 100,000 people: 1.6

Percent of total deaths: 0.20%

Cause is most prevalent in: Alabama (6.28 deaths per 100,000 people)

Blood pumping throughout the body is an essential facet of human life; it enables people to move limbs freely, breathe comfortably, and experience sensations via the nervous system. Some common indicators that one’s heart is  include swelling in one’s legs and feet, weakness and fatigue, and excessive wheezing or other exercise-related difficulties. 

Deaths due to this cause: 91,234

Deaths per 100,000 people: 1.7

Percent of total deaths: 0.20%

Cause is most prevalent in: Hawaii (2.77 deaths per 100,000 people)

While incredibly rare, subarachnoid haemorrhage—strokes resulting from bleeding on the surface of the brain—typically come with little or no warning, but often prove to be the byproduct of certain sorts of physical activity. People have typically experienced them while undergoing  such as working out, having sex, or even coughing. 

Deaths due to this cause: 91,898

Deaths per 100,000 people: 1.7

Percent of total deaths: 0.20%

Cause is most prevalent in: Montana (3.09 deaths per 100,000 people)

Endocarditis refers to an infection of one’s endocardium, which is the thin membrane connecting the heart’s multiple blood valves. While the disease is serious if not treated properly, seeing as it has resulted in tens of thousands of deaths in recent decades, it is typically treatable—either by the use of  in more extreme cases. 

Deaths due to this cause: 93,530

Deaths per 100,000 people: 1.7

Percent of total deaths: 0.21%

Cause is most prevalent in: Maine (4.68 deaths per 100,000 people)

While cardiovascular disease and heart disease are closely related, heart disease refers to complications with the organ itself, whereas cardiovascular disease can affect any active part of the cardiovascular system. Many problems which can be labeled as examples of cardiovascular disease result from instances of , the buildup of plaque in one’s artery walls that can result in constricted blood flow.

Deaths due to this cause: 94,816

Deaths per 100,000 people: 1.7

Percent of total deaths: 0.21%

Cause is most prevalent in: Alabama (3.23 deaths per 100,000 people)

Short-term instances of anoxic brain injuries, a condition in which the brain is deprived of oxygen for an extensive period of time, can be , causing minor troubles concentrating and dizziness. In more serious cases, however, depriving the brain of oxygen can result in impairment of one’s  and even cause death.

Deaths due to this cause: 97,010

Deaths per 100,000 people: 1.8

Percent of total deaths: 0.22%

Cause is most prevalent in: Rhode Island (4.49 deaths per 100,000 people)

Enterocolitis refers to inflammation of the inner lining of one’s digestive track, more specifically the large intestine. Though Clostridium difficile (known commonly as C-dif) is a bacterium best known for , it can also ultimately lead to the scarring associated with various forms of colitis—which can result in serious injury and even death if not treated properly.

Deaths due to this cause: 97,826

Deaths per 100,000 people: 1.8

Percent of total deaths: 0.22%

Cause is most prevalent in: South Dakota (2.91 deaths per 100,000 people)

Myelodysplastic syndromes result from the improper formation of blood cells, rendering them incapable of performing their proper functions. While fatigue, shortness of breath, and frequent infections are symptoms that do not necessarily indicate a serious problem, patients whose skin breaks out in , tiny red dots representative of subsurface bleeding, ought to consult with a physician.

Deaths due to this cause: 100,511

Deaths per 100,000 people: 1.8

Percent of total deaths: 0.22%

Cause is most prevalent in: South Carolina (3 deaths per 100,000 people)

Cerebral infarctions, known more commonly as strokes, occur in people whose brains experience a sudden  to a certain region for a variety of reasons. This loss of oxygen translates into the damage of several key tissues in the brain, which in severe cases can cause patients to experience reduced motor skills, language difficulties, loss of sentience, or death.

Deaths due to this cause: 101,017

Deaths per 100,000 people: 1.9

Percent of total deaths: 0.22%

Cause is most prevalent in: Oklahoma (3.09 deaths per 100,000 people)

Diabetes mellitus is a disease that has the capacity to attack the body in a myriad of ways, not the least of which is by targeting the kidneys. Though it is difficult to guarantee with absolute certainty the avoidance of renal failure with any serious diseases, physicians recommend the administration of drugs such as to help alleviate symptoms.

Deaths due to this cause: 102,088

Deaths per 100,000 people: 1.9

Percent of total deaths: 0.23%

Cause is most prevalent in: Alabama (6.01 deaths per 100,000 people)

Though  Americans are living with congestive heart failure (CHF), the statistics pertaining to the survival rates of those diagnosed are far less encouraging. Emory Healthcare claims that  of individuals who contract CHF die within five years of their diagnosis.
 

Deaths due to this cause: 105,393

Deaths per 100,000 people: 1.9

Percent of total deaths: 0.23%

Cause is most prevalent in: Rhode Island (3.21 deaths per 100,000 people)

A blockage of blood flow to the intestines can cause a handful of serious problems for the health of one’s internal organs. Though the digestive system and cardiovascular system are typically thought of as separate in medical terms, the two are incredibly co-dependent. Diseases relating to the failure of their collaborative functions are much more common later in life, primarily in people . 

Deaths due to this cause: 106,346

Deaths per 100,000 people: 2

Percent of total deaths: 0.24%

Cause is most prevalent in: Louisiana (3.88 deaths per 100,000 people)

Chronic kidney disease, or CKD, is perhaps one of the scariest infections in existence, since it often exhibits no symptoms and proves incredibly difficult to detect. Though signs of it usually appear in blood tests, it is common for the disease to only become apparent once  has been done to one's kidneys.

Deaths due to this cause: 110,986

Deaths per 100,000 people: 2

Percent of total deaths: 0.25%

Cause is most prevalent in: West Virginia (4.4 deaths per 100,000 people)

Hyperlipidemia refers to excessive lipids that can lead to a buildup of plaque in one’s arteries. It is amongst the most preventable tragedies on this list, and people can ward off bad cholesterol by taking active measures to maintain a , whether it be eating well, exercising with greater frequency, or avoiding smoking of all forms.

Deaths due to this cause: 111,774

Deaths per 100,000 people: 2.1

Percent of total deaths: 0.25%

Cause is most prevalent in: Washington (3.66 deaths per 100,000 people)

Though Alzheimer’s disease accounts for a whopping  of all dementia cases and has a far larger death toll, vascular dementia is another harmful condition that impacts mental function. It results from a severe lack of blood flow to one’s brain, and is extremely common in .

Deaths due to this cause: 112,854

Deaths per 100,000 people: 2.1

Percent of total deaths: 0.25%

Cause is most prevalent in: Vermont (3.48 deaths per 100,000 people)

Motor neuron diseases come in many forms and can occur in both children and adults. Symptoms can present themselves even before an infant , though they can appear seemingly out of nowhere in adults. Such was the case with Yankees legend , whose case of amyotrophic lateral sclerosis (ALS) reared its ugly head late in the first baseman’s career. It eventually became known as “Lou Gehrig’s Disease” in his honor.

Deaths due to this cause: 115,002

Deaths per 100,000 people: 2.1

Percent of total deaths: 0.26%

Cause is most prevalent in: New Mexico (10.5 deaths per 100,000 people)

Though falling from high surfaces is something that many people fear, a dangerous fall can occur from any level. Falling is something most people have experienced with little to no major consequences, but they are  in the case of elderly individuals—whose fragile bones are more susceptible to breaking when coming in contact with hard surfaces.

Deaths due to this cause: 115,315

Deaths per 100,000 people: 2.1

Percent of total deaths: 0.26%

Cause is most prevalent in: Pennsylvania (5.04 deaths per 100,000 people)

Cerebrovascular disease refers to any a breakdown in adequate blood flow to the brain, and can include a , including strokes, aneurysms, and vascular malformations. Since arteries are not typically seen in X-rays, physicians encourage people who fear they may be at risk to get either a CT or CAT scan, a cerebral angiography, or a carotid ultrasound.

Deaths due to this cause: 118,113

Deaths per 100,000 people: 2.2

Percent of total deaths: 0.26%

Cause is most prevalent in: West Virginia (3.31 deaths per 100,000 people)

Though it may not be part of your everyday routine to check in on the quality of your stools, making a habit of doing so can be instrumental in saving one’s life. Rectal cancer shows a great many symptoms in patients, including weakness, fatigue, and random weight loss—though the ones that are more easily distinguishable from other forms of illness are those pertaining to fecal aberrations, including the  in one’s bowel movements. 

Deaths due to this cause: 118,364

Deaths per 100,000 people: 2.2

Percent of total deaths: 0.26%

Cause is most prevalent in: Oregon (4.03 deaths per 100,000 people)

Though cardiovascular diseases prove harmful in and of themselves, the resulting sequelae (long-term conditions) can also cause death. These include , where the heart beats at an exceedingly irregular rate, and in severe cases can end in cardiac arrest.

Deaths due to this cause: 121,181

Deaths per 100,000 people: 2.2

Percent of total deaths: 0.27%

Cause is most prevalent in: Mississippi (5.1 deaths per 100,000 people)

As is the case with most cancers, anybody can be at risk, but liver cancer is a type of the disease that is found more often in a select group of people. Individuals with the viruses of hepatitis B or hepatitis C are the  to contract liver cancer, though heavy drinkers and obese individuals also more susceptible than the rest of the general public.

Deaths due to this cause: 125,059

Deaths per 100,000 people: 2.3

Percent of total deaths: 0.28%

Cause is most prevalent in: Louisiana (5.15 deaths per 100,000 people)

End-stage renal disease, or ESRD, refers to the final stage in a five-stage progression of chronic kidney disease, which is indicated by a very low —the speed at which one’s kidneys can remove waste.

Deaths due to this cause: 125,650

Deaths per 100,000 people: 2.3

Percent of total deaths: 0.28%

Cause is most prevalent in: West Virginia (3.44 deaths per 100,000 people)

There are a handful of ways in which clogging of one's arteries can have lethal results. In the case of a peripheral vascular disease, blood flow to the limbs is cut off—often causing a patient  in one's arms and legs—and is fatal in severe cases.

Deaths due to this cause: 131,324

Deaths per 100,000 people: 2.4

Percent of total deaths: 0.29%

Cause is most prevalent in: West Virginia (4.21 deaths per 100,000 people)

While many diseases brew in one’s system over an extended period of time, acute kidney failure can develop over the course of a few days—or . Though kidney failure can vary in degree of severity, proper treatment in healthier individuals can lead to a full or close-to-full return to health. 

Deaths due to this cause: 136,942

Deaths per 100,000 people: 2.5

Percent of total deaths: 0.30%

Cause is most prevalent in: Hawaii (4.37 deaths per 100,000 people)

Of the various malignancies of the liver, hepatocellular carcinoma is the  by far—and occurs more frequently in men than in women. It usually results from cirrhosis, or scarring of the liver, which can happen in a myriad of cases, but is more likely in individuals who drink alcohol excessively or suffer from , an overload of iron in one’s system.

Deaths due to this cause: 137,517

Deaths per 100,000 people: 2.5

Percent of total deaths: 0.31%

Cause is most prevalent in: West Virginia (4.84 deaths per 100,000 people)

Chronic renal failure (CKD) is a multi-stage process that has potentially fatal consequences at various stages. Since it can be difficult to determine which stage of CKD the victim was experiencing at the time of death, many are simply labeled unspecified  the patient’s experience. 

Deaths due to this cause: 137,639

Deaths per 100,000 people: 2.5

Percent of total deaths: 0.31%

Cause is most prevalent in: Nevada (3.93 deaths per 100,000 people)

Accounting for about a 10th of all strokes in the United States, intracranial haemorrhages are not uncommon in athletes who experience regular head-to-head contact. The NFL has taken measures in recent years to make the game safer for its players, whose trauma-inducing hits can cause them to experience a great deal of .

Deaths due to this cause: 138,933

Deaths per 100,000 people: 2.6

Percent of total deaths: 0.31%

Cause is most prevalent in: West Virginia (3.73 deaths per 100,000 people)

Skin cancer comes in many forms, with melanoma the most dangerous: It kills  people in the United States every year. One way to detect melanoma is the presence of ; experts advise getting in contact with a physician, as asymmetry is often indicative of a malignancy. 

Deaths due to this cause: 139,846

Deaths per 100,000 people: 2.6

Percent of total deaths: 0.31%

Cause is most prevalent in: Pennsylvania (4.39 deaths per 100,000 people)

Often referred to as GI bleeding, gastrointestinal haemorrhages can occur anywhere in the digestive tract, whether that’s the esophagus, the small or large intestine, the rectum, or the anus. Though the symptoms are somewhat disturbing, they’re fairly easy to recognize: The  advises checking for discolored or abnormally textured stool and vomit.  

Deaths due to this cause: 143,273

Deaths per 100,000 people: 2.6

Percent of total deaths: 0.32%

Cause is most prevalent in: Arkansas (4.97 deaths per 100,000 people)

A pulmonary embolism is when one of the two arteries in the lungs experiencing a blockage. While this can often result an acute cor pulmonale, or right heart failure, there are instances of pulmonary embolisms bringing about death in other ways. However, these can be prevented more easily with continued positive treatment of one’s legs, whether that means . 

Deaths due to this cause: 144,628

Deaths per 100,000 people: 2.7

Percent of total deaths: 0.32%

Cause is most prevalent in: Arkansas (6.1 deaths per 100,000 people)

When people on life support flatline, it represents the most severe example of a cardiac arrhythmia, which is defined by an abnormal sequencing of electrical impulses to the heart. This disruption of impulses may infringe on the heart’s ability to pump blood as normal, which can result in complications for  throughout the body.

Deaths due to this cause: 152,078

Deaths per 100,000 people: 2.8

Percent of total deaths: 0.34%

Cause is most prevalent in: Iowa (3.84 deaths per 100,000 people)

Acute myeloid leukemia, which occurs when one’s bone marrow produces abnormal white blood cells, has a negative effect on one’s pre-existing healthy blood cells. The cancer is named after myeloid stem cells, which are  the faulty white blood cells.

Deaths due to this cause: 152,684

Deaths per 100,000 people: 2.8

Percent of total deaths: 0.34%

Cause is most prevalent in: Hawaii (5.6 deaths per 100,000 people)

Though there are many means by which people intentionally bring an end to their own lives, suffocation by means of hanging and other forms of strangulation are still upsettingly common in the year 2018.

Deaths due to this cause: 164,994

Deaths per 100,000 people: 3

Percent of total deaths: 0.37%

Cause is most prevalent in: Kansas (13.02 deaths per 100,000 people)

The  does a good job of summarizing atherosclerosis, or fatty deposits, which clog one’s arteries with plaque buildup: “a big word for a big problem.” While atherosclerosis can occur in many parts of the body, it is oftentimes unclear which arteries being clogged lead most directly to a person’s death.

Deaths due to this cause: 167,586

Deaths per 100,000 people: 3.1

Percent of total deaths: 0.37%

Cause is most prevalent in: District of Columbia (5.21 deaths per 100,000 people)

Increased blood pressure as a result of kidney failure can be recognized in a handful of ways, though it is not uncommon to experience no symptoms whatsoever. Many people with renal hypertension never undergo the  typically associated with it. 

Deaths due to this cause: 171,789

Deaths per 100,000 people: 3.2

Percent of total deaths: 0.38%

Cause is most prevalent in: Arkansas (5.18 deaths per 100,000 people)

While strokes themselves are incredibly dangerous, survivors more often than not experience symptoms long thereafter that can also prove to be fatal. After experiencing a stroke, most people feel , and can develop emotional and cognitive changes over time without even realizing it.

Deaths due to this cause: 183,788

Deaths per 100,000 people: 3.4

Percent of total deaths: 0.41%

Cause is most prevalent in: New Mexico (6.9 deaths per 100,000 people)

Cirrhosis of the liver can come about in a handful of ways, but it’s most directly associated with alcohol abuse. While men are more likely to contract alcoholic liver disease than women, women typically require less  over the course of their respective lifetimes in order to get cirrhosis.

Deaths due to this cause: 184,285

Deaths per 100,000 people: 3.4

Percent of total deaths: 0.41%

Cause is most prevalent in: District of Columbia (18.64 deaths per 100,000 people)

Gun violence is a serious epidemic in the United States—more than any other country in the world—and it has only gotten worse in recent years. Not only are isolated incidents of murder by firearms on the rise, there have already been  across the country in 2018—which checks out to be approximately one every single week.

Deaths due to this cause: 190,917

Deaths per 100,000 people: 3.5

Percent of total deaths: 0.43%

Cause is most prevalent in: Alabama (10.43 deaths per 100,000 people)

A less noticeable, but equally disturbing trend in recent years has been the amount of motor-vehicle accidents that have caused death. Whether by accident or intentional, people die every day from neglectful driving—and events like those in Nice, France, and Charlottesville, Va. also serve to underscore the damage that drivers with malicious intents are capable of.
 

Deaths due to this cause: 192,928

Deaths per 100,000 people: 3.5

Percent of total deaths: 0.43%

Cause is most prevalent in: Mississippi (9.48 deaths per 100,000 people)

Hypertensive heart disease can render itself in a few different forms, with  both proving incredibly common amongst those with high blood pressure. While high blood pressure can be passed down hereditarily, it is also something that can result from not engaging in healthy activities, such as smoking or eating fatty, cholesterol-heavy foods. 

Deaths due to this cause: 195,032

Deaths per 100,000 people: 3.6

Percent of total deaths: 0.43%

Cause is most prevalent in: Hawaii (6.81 deaths per 100,000 people)

Stomach cancer, as with most cancers, does not happen exclusively to any one particular group of people, there are a  that point to certain people’s increased likelihood of contracting it. In the United States, stomach cancer is seen most commonly in elderly individuals, with men experiencing the disease  than women.

Deaths due to this cause: 198,643

Deaths per 100,000 people: 3.7

Percent of total deaths: 0.44%

Cause is most prevalent in: Minnesota (8.5 deaths per 100,000 people)

Falling is something that is present in the minds of many fliers, skiers, and other people who have to travel to high altitudes from which they could hypothetically suffer a serious fall. As such, many people have developed a fear of high places known as acrophobia, which  stems from a desire to be “in control” going unfulfilled.

Deaths due to this cause: 198,774

Deaths per 100,000 people: 3.7

Percent of total deaths: 0.44%

Cause is most prevalent in: District of Columbia (4.87 deaths per 100,000 people)

Multiple myeloma forms in a white blood cell known as a plasma cell, whose purpose is to help fight off disease by making antibodies, which ward of germs. While the cancer is difficult to detect because the symptoms vary with some irregularity, there are  that can call for a worthwhile doctor visit, including: excessive thirst, weak legs, reduced desire to eat, and bone pain in the mid-section.

Deaths due to this cause: 199,164

Deaths per 100,000 people: 3.7

Percent of total deaths: 0.44%

Cause is most prevalent in: West Virginia (7.48 deaths per 100,000 people)

Chronic obstructive pulmonary disease, or COPD, refers to lung diseases like bronchitis and emphysema, which can make it exceedingly difficult to breathe. The disease is rarely fatal, however, and many people have lived successful lives with it throughout history—including  like Dean Martin and Johnny Carson.

Deaths due to this cause: 203,317

Deaths per 100,000 people: 3.7

Percent of total deaths: 0.45%

Cause is most prevalent in: North Carolina (15.66 deaths per 100,000 people)

Ischaemic heart disease refers to a myriad of heart problems—stemming from arteries to the heart being narrowed, resulting in a lack of oxygen and blood being transmitted to the muscle. Many Americans suffer from , or the state of experiencing ischemia without feeling pain, which sounds nice in theory, except that it can result in one suffering from a heart attack with no warning.

Deaths due to this cause: 206,640

Deaths per 100,000 people: 3.8

Percent of total deaths: 0.46%

Cause is most prevalent in: Montana (8.98 deaths per 100,000 people)

Proponents of gun control often point to the fact that easy access to firearms not only allows people the opportunity to inflict harm on others, but on themselves as well. More than 21,000 Americans die by way of  annually—a fact that could have something to do with the fact that fewer than 10% of suicide attempts not involving a gun are successful, while 90% of gun suicides are successful. 

Deaths due to this cause: 214,558

Deaths per 100,000 people: 3.9

Percent of total deaths: 0.48%

Cause is most prevalent in: Arkansas (6.48 deaths per 100,000 people)

Emphysema is a respiratory disease that can result from exposure to tobacco or marijuana smoke, though it can also be contracted by being surrounded by low-quality air and various chemical fumes. This may explain why the disease is most prevalent in Arkansas, whose capital Little Rock is one of the  in the United States.

Deaths due to this cause: 216,854

Deaths per 100,000 people: 4

Percent of total deaths: 0.48%

Cause is most prevalent in: Maine (5.87 deaths per 100,000 people)

Interstitial pulmonary diseases refers to a handful of disorders stemming from the internal scarring of lung tissue, which can hinder oxygen flow and make breathing exceedingly difficult. Pulmonary fibrosis can be observed by a dry cough, excessive aching in joints and certain muscles, , which refers to the widening and rounding of fingertips and toes.
 

Deaths due to this cause: 218,459

Deaths per 100,000 people: 4

Percent of total deaths: 0.49%

Cause is most prevalent in: Florida (8.74 deaths per 100,000 people)

Ischemic CMs are the most common type of dilated cardiomyopathy, in which the heart is less able to pump blood as normal because the left ventricle is enlarged and weak. Often the result of , ischemic CMs can be identified by a wide array of symptoms—some of which include chest palpitations and weight gain by fluid retention. 

Deaths due to this cause: 220,100

Deaths per 100,000 people: 4

Percent of total deaths: 0.49%

Cause is most prevalent in: Oregon (8.92 deaths per 100,000 people)

When the heart’s aortic valve becomes increasingly narrowed, aortic valve stenosis blocks blood from passing from one’s heart to their aorta. The disease oftentimes becomes apparent in the form of occasional  and will regularly require surgery in order to repair or replace the valve.
 

Deaths due to this cause: 223,649

Deaths per 100,000 people: 4.1

Percent of total deaths: 0.50%

Cause is most prevalent in: West Virginia (9.49 deaths per 100,000 people)

In West Virginia, the nation’s leader in per-capita diabetes deaths, it is estimated that nearly a quarter of a million people carry the disease. The Mountain State is right to call the disease a local epidemic, since approximately 12% of West Virginian adults have received a diabetes diagnosis from their physician. 

Deaths due to this cause: 226,016

Deaths per 100,000 people: 4.2

Percent of total deaths: 0.50%

Cause is most prevalent in: District of Columbia (9.73 deaths per 100,000 people)

Poisoning from narcotic overdose is something that happens to intentional opioid users all too regularly, but even seemingly “safer” drugs carry comparable risks when one considers the dangers of mixing. For example, while cannabis may be perceived as relatively safe in the eyes of many, it has the potential to be  and carry their toxic effects with it without the person realizing. 

Deaths due to this cause: 228,425

Deaths per 100,000 people: 4.2

Percent of total deaths: 0.51%

Cause is most prevalent in: West Virginia (5.69 deaths per 100,000 people)

Unlike other forms of cancer throughout the body, kidney cancer , and it can be recognized a few ways. For one, patients with kidney cancer are likely to experience mild-to-severe back pain; those affected experience blood in their urine to the point that it appears pink or even cola-colored. 
 

Deaths due to this cause: 228,784

Deaths per 100,000 people: 4.2

Percent of total deaths: 0.51%

Cause is most prevalent in: West Virginia (12.47 deaths per 100,000 people)

The  warns of poisons which can be found among the most basic household items. Among the most common are glue, paints, markers, and laundry packets, all of which are easily accessible and consumable by children, and should be kept out of reach.

Deaths due to this cause: 229,272

Deaths per 100,000 people: 4.2

Percent of total deaths: 0.51%

Cause is most prevalent in: Rhode Island (6.99 deaths per 100,000 people)

UTIs are much more common in women than men, and they can originate in several locations throughout one’s urinary tract. Though a  like cloudy urine or increased urgency are universal, different parts of the urinary tract being affected give off their own .

Deaths due to this cause: 231,747

Deaths per 100,000 people: 4.3

Percent of total deaths: 0.52%

Cause is most prevalent in: Maine (5.78 deaths per 100,000 people)

Brain tumors can originate within the brain, or start in other parts of the body and move toward the brain. It is obviously difficult for a patient to know they may be at risk without a professional medical diagnosis, but a few  that one may have a tumor, either benign or malignant, include difficulty with balance, a loss of feeling in various limbs, or random nausea.

Deaths due to this cause: 240,445

Deaths per 100,000 people: 4.4

Percent of total deaths: 0.54%

Cause is most prevalent in: District of Columbia (17.97 deaths per 100,000 people)

In the 1993 classic “Groundhog Day,” a nurse at the emergency room regrettably tells a grieving Bill Murray,   Though medical professionals do their best to find a tangible cause for every death, there are many cases where the autopsy does not reveal a clear indication of why a person passed.

Deaths due to this cause: 245,771

Deaths per 100,000 people: 4.5

Percent of total deaths: 0.55%

Cause is most prevalent in: Maine (7.26 deaths per 100,000 people)

Cancer of the esophagus comes about when a collection of cells in one's food pipe grow in an unregulated, uncontrolled manner; it can develop in the upper or lower esophagus . Esophageal cancer occurs  in men than women, and has a somewhat discouraging five-year survival rate at only 19%.

Deaths due to this cause: 251,918

Deaths per 100,000 people: 4.6

Percent of total deaths: 0.56%

Cause is most prevalent in: Maine (7.29 deaths per 100,000 people)

Unlike other cancers, cancer of the bladder carries with it a unique set of symptoms—most generally typified by frequent, painful, and bloody urination. Older white men are at a  to contract the disease than the general public, and some of the key risk factors include smoking or exposure to some chemicals. 

Deaths due to this cause: 253,635

Deaths per 100,000 people: 4.7

Percent of total deaths: 0.56%

Cause is most prevalent in: Alabama (37.21 deaths per 100,000 people)

Cardiac arrest and heart attacks are  as being the same thing, though heart attacks occur during a loss of blood supply while a cardiac arrest is the result of a malfunction of the heart’s electrical system. Fans of the King of Pop may remember that cardiac arrest is what took the life of Michael Jackson when he  nearly 10 years ago.

Deaths due to this cause: 259,155

Deaths per 100,000 people: 4.8

Percent of total deaths: 0.58%

Cause is most prevalent in: Pennsylvania (6.03 deaths per 100,000 people)

Oscar-winning actress Kathy Bates is known for roles like Molly Brown in “Titanic,” but she’s also one of the most well-known living advocates of ovarian cancer awareness. She was able to successfully overcome the disease she was diagnosed with back in 2003, due in a large part to the fact that she reached out to a physician when she noticed her bloating and constant urge to urinate. 
 

Deaths due to this cause: 266,210

Deaths per 100,000 people: 4.9

Percent of total deaths: 0.59%

Cause is most prevalent in: West Virginia (6.95 deaths per 100,000 people)

Named for the English physician , both Hodgkin’s lymphoma and non-Hodgkin’s lymphoma are cancers of the lymphatic system—the network of disease-fighting mechanisms located throughout the body. Non-Hodgkin’s may render itself in the form of many symptoms indicative of  against disease, whether that’s painful lymph nodes, fever, fatigue, or night sweats.

Deaths due to this cause: 266,233

Deaths per 100,000 people: 4.9

Percent of total deaths: 0.59%

Cause is most prevalent in: Arkansas (9.63 deaths per 100,000 people)

Renal failure can be either acute or chronic, which means it could either be the result of a long-lasting kidney disease that was bound to culminate in discontinued functioning, or a sudden shutdown with no warning. Though kidney failures account for more than one in every 200 deaths,  such as Halle Berry, Selena Gomez, and Sarah Hyland are all successfully living their best lives in spite of serious kidney issues.

Deaths due to this cause: 270,889

Deaths per 100,000 people: 5

Percent of total deaths: 0.60%

Cause is most prevalent in: Oregon (9.77 deaths per 100,000 people)

As in the case with cardiac arrest, atrial flutter and fibrillations refer to the irregular functioning of the heart’s electrical system. Though other diseases can be hard to recognize, simply  and noticing anything out of the ordinary can be a strong indicator of fibrillations or flutter.

Deaths due to this cause: 273,153

Deaths per 100,000 people: 5

Percent of total deaths: 0.61%

Cause is most prevalent in: Hawaii (6.99 deaths per 100,000 people)

Intracerebral 2  through seizures, confusion, vision loss, and a handful of other symptoms that point to the brain functioning at a subpar level. Though the condition is impossible to prevent altogether, it’s commonly the result of strenuous physical activity.

Deaths due to this cause: 275,281

Deaths per 100,000 people: 5.1

Percent of total deaths: 0.61%

Cause is most prevalent in: West Virginia (8.88 deaths per 100,000 people)

Liver cirrhosis is a common cause of death, and scientists have conducted experiments in recent years to find a cure for the many people it impacts. Researchers from  that the infusion of anti-fibrotic vascular cells can help rebuild damaged structures in the walls of the liver.
 

Deaths due to this cause: 280,918

Deaths per 100,000 people: 5.2

Percent of total deaths: 0.63%

Cause is most prevalent in: Mississippi (9.97 deaths per 100,000 people)

High blood pressure, known as hypertension, can result in a series of serious and often fatal health complications—though secondary complications may be unclear at the time of diagnosis. Hypertension can be hereditary and uncontrollable, though it can often be triggered by a myriad of  such as diet and lack of physical activity.

Deaths due to this cause: 314,521

Deaths per 100,000 people: 5.8

Percent of total deaths: 0.70%

Cause is most prevalent in: Connecticut (9.95 deaths per 100,000 people)

Pneumonitis refers to the inflammation of the alveoli in the lungs brought about by the introduction of a harmful substance to the body, be that drugs, radiation treatments, or exposure to . Food can often trigger the disease as well, and the regularity with which mold has carried the disease to people's lungs has earned certain varieties of bacteria-based pneumonitis the , "farmer's lung" and "hot tub lung."

Deaths due to this cause: 326,831

Deaths per 100,000 people: 6

Percent of total deaths: 0.73%

Cause is most prevalent in: Florida (10.06 deaths per 100,000 people)

A big contributor to many eventual heart failures, cardiomyopathies occur when the heart muscle is unable to pump blood to the remainder of one’s body. Though these are not entirely preventable, as  are each common causes, one can lower their chances of experiencing a cardiomyopathy by avoiding binge drinking and the consumption of stimulant drugs such as cocaine.

Deaths due to this cause: 375,447

Deaths per 100,000 people: 6.9

Percent of total deaths: 0.84%

Cause is most prevalent in: Maine (9.44 deaths per 100,000 people)

 as ‘paralysis agitans’ by Dr. James Parkinson in 1817, and then later named in his honor by Dr. Jean-Martin Charcot, the disease has received increasingly more recognition in recent years as a result of powerful awareness campaigns. Behind the voices of affected celebrities, including Michael J. Fox, people have rallied together to fight the disease by raising money and spreading valuable information—especially during April, which is officially recognized as .

Deaths due to this cause: 380,761

Deaths per 100,000 people: 7

Percent of total deaths: 0.85%

Cause is most prevalent in: District of Columbia (29.08 deaths per 100,000 people)

When beloved comedian Ralphie May passed away on Oct. 7, 2017, it served as a reminder to people about the immense dangers of overeating to the point that one’s  to uncontrollable levels. What is so especially dangerous about hypertension,  of the University of Virginia, is that it can put pressure against the walls of one’s arteries without the patient feeling anything until irreversible damage has been done to their internal organs.

Deaths due to this cause: 474,749

Deaths per 100,000 people: 8.7

Percent of total deaths: 1.06%

Cause is most prevalent in: West Virginia (14.49 deaths per 100,000 people)

While cancer is detrimental enough when its origin site is clear to the doctors responsible for treating it, it is even more volatile and dangerous when the source proves entirely unclear. Certain cancers are untreatable altogether, though having knowledge of the primary site allows medical professionals the opportunity  with a better idea of what steps may be best suited to the prevention of further spreading.

Deaths due to this cause: 524,480

Deaths per 100,000 people: 9.6

Percent of total deaths: 1.17%

Cause is most prevalent in: District of Columbia (13.87 deaths per 100,000 people)

Every September, the  encourages people to "Step up for Blue" and help fight the second most common cancer in American men. Contributions to research efforts combating the disease in recent years have not only paved the way for a significant decrease in the prostate cancer death rate, but have also subsequently played roles in  in nine other cancers.
 

Deaths due to this cause: 582,716

Deaths per 100,000 people: 10.7

Percent of total deaths: 1.30%

Cause is most prevalent in: New Jersey (19.92 deaths per 100,000 people)

Septicemia refers to any poisoning of the blood by the same collection of germs, which can lead to meningitis, and it results from a large amount of bacteria entering the bloodstream. Since the illness worsens progressively as more bacteria infiltrate the bloodstream, septicemia is something that can be more easily reversed if caught in its earlier stages,  faintness, pale and clammy skin, and abnormally high body temperature.

Deaths due to this cause: 623,801

Deaths per 100,000 people: 11.5

Percent of total deaths: 1.39%

Cause is most prevalent in: Pennsylvania (14.33 deaths per 100,000 people)

One of the most brutal variations of cancer, pancreatic cancer claims  of patients within five years of diagnosis, making it easily one of the most irreversible malignancies. It is unsurprising that approximately 75% of cases are seen in  of 55 and 84, seeing as the disease can more easily affect the pancreas when one’s defense mechanisms progressively weaken over time with aging.

Deaths due to this cause: 679,735

Deaths per 100,000 people: 12.5

Percent of total deaths: 1.51%

Cause is most prevalent in: Louisiana (21.54 deaths per 100,000 people)

Though the small percentage of diabetes patients diagnosed with Type 1 usually receive the news , in which they could not have done anything to prevent it, approximately 85% of patients suffer from Type 2, which is more often than not the result of lack of exercise, poor diet, or a combination of the two. While Type 1 patients require daily insulin shots to manage their health, those with Type 2 are  the disease by taking active measures to improve their diet and maintain a generally healthy lifestyle.

Deaths due to this cause: 747,671

Deaths per 100,000 people: 13.8

Percent of total deaths: 1.66%

Cause is most prevalent in: Pennsylvania (17.22 deaths per 100,000 people)

With the  in 2018, breast cancer is not only the most commonly diagnosed variation of the deadly disease, but it is arguably the most widely recognized as well. Activism against the infection has been most heavily channeled through the sports world in recent years, as the National Football League dedicated October to the color pink in order to raise awareness until they decided to  to allow teams to take efforts toward fighting a disease of their choice. 

Deaths due to this cause: 763,970

Deaths per 100,000 people: 14.1

Percent of total deaths: 1.70%

Cause is most prevalent in: West Virginia (20.47 deaths per 100,000 people)

The majority of colon cancer instances begin with the formation of benign cell clumps known as , which can sometimes develop into malignancies. Though cases are variable as with any other cancer, patients who transition from diets that are high in fiber and low in fat to diets that more traditionally , have proven more susceptible to develop colon cancer. 

Deaths due to this cause: 878,985

Deaths per 100,000 people: 16.2

Percent of total deaths: 1.96%

Cause is most prevalent in: Arkansas (23.93 deaths per 100,000 people)

The ninth president of the United States, William Henry Harrison, is famously said to have died only a month into his term as a result of pneumonia he contracted while delivering his  without a hat, coat, or gloves in the pouring rain. While scientists have since suggested that may have not quite been the case, the disease is still rampant today and  by excessive coughing, abnormally severe fever, and shaky chills. 

Deaths due to this cause: 986,287

Deaths per 100,000 people: 18.1

Percent of total deaths: 2.20%

Cause is most prevalent in: Mississippi (40.93 deaths per 100,000 people)

Heart failure manifests itself in a handful of ways and as a result, it can be recognized by a wide . Lower-body swelling and trouble breathing may indicate a side-specific failure in the right and left ventricles, respectively, whereas difficulty either in pumping blood throughout the body or receiving blood in the heart itself could indicate either a  heart failure.

Deaths due to this cause: 1,125,283

Deaths per 100,000 people: 20.7

Percent of total deaths: 2.51%

Cause is most prevalent in: District of Columbia (84.62 deaths per 100,000 people)

Though atherosclerosis represents a sizable portion of annual deaths in the United States, be it of the cardiovascular or heart-specific variety, scientists are developing more technologically savvy ways of fighting it every single day. Studies out of the Baylor College of Medicine have  are capable of indicating to medical professionals that cardiovascular disease may be approaching before it affects individuals. 

Deaths due to this cause: 1,332,232

Deaths per 100,000 people: 24.5

Percent of total deaths: 2.97%

Cause is most prevalent in: Arkansas (37.12 deaths per 100,000 people)

An eerie statistic to imagine is the fact that somebody suffers from a stroke  in the United States. While young people do have some risk of experiencing one, more than three-quarters of all reported strokes occur after the age of 65, and nearly a decade after people’s risk of experiencing one more than doubles.

Deaths due to this cause: 1,332,563

Deaths per 100,000 people: 24.5

Percent of total deaths: 2.97%

Cause is most prevalent in: North Dakota (46.96 deaths per 100,000 people)

Sports fans everywhere wept on June 28, 2016 when Alzheimer's took Pat Summitt, the winningest coach in the history of college basketball. The pride of Nashville and eight-time National Collegiate Athletic Association-tournament winner has left a legacy that is , and the foundation named in her honor actively fights Alzheimer's by seeking to fund research and provide educational resources for young people.

Deaths due to this cause: 1,381,584

Deaths per 100,000 people: 25.4

Percent of total deaths: 3.08%

Cause is most prevalent in: Maine (42.47 deaths per 100,000 people)

While dementia is typically associated with Alzheimer’s, the term ‘dementia’ is technically a symptom describing one’s  to the point that it interferes with everyday functions, and it is seen in a handful of diseases. Since dementia is easy to spot, but its associated disease is more difficult to diagnose as a result of , doctors often deem it sufficient to diagnose the patient with “unspecified dementia.”
 

Deaths due to this cause: 1,838,159

Deaths per 100,000 people: 33.8

Percent of total deaths: 4.09%

Cause is most prevalent in: West Virginia (60.07 deaths per 100,000 people)

Often specified as emphysema, an inflammation of the alveoli, or bronchitis, and inflammation of the bronchial tubes, COPD is often easy to diagnose, but difficult to specify in terms of the region being most directly impacted. Though the disease is clearly amongst the most prevalent causes of death in the United States, contracting it is not necessarily a death sentence, since stars such as NASCAR racer Danica Patrick have  with careers heavily dependant on a reliable respiratory system.

Deaths due to this cause: 2,574,756

Deaths per 100,000 people: 47.4

Percent of total deaths: 5.73%

Cause is most prevalent in: Arkansas (106.9 deaths per 100,000 people)

Better known colloquially as ‘heart attacks,’ acute myocardial infarctions take place when one’s blocked coronary artery causes the heart muscle to suffer from a lack of blood supply. Though they are often difficult to detect until they strike, one can sometimes  on the horizon when experiencing extreme chest pain, cold sweats, and lightheadedness or dizziness. 

Deaths due to this cause: 2,799,377

Deaths per 100,000 people: 51.5

Percent of total deaths: 6.23%

Cause is most prevalent in: West Virginia (81.89 deaths per 100,000 people)

In a world with not so many objective truths, one thing will always be for certain: smoking cigarettes is the most detrimental thing people can do to their lungs. While there exists the notion that chronic smokers will get lung cancer regardless and may as well keep smoking as a result, the Mayo Clinic reminds smokers that risk is progressively , and that quitting at any stage is worthwhile in the hopes of avoiding the nation’s most deadly variant of cancer.

Deaths due to this cause: 3,396,232

Deaths per 100,000 people: 62.5

Percent of total deaths: 7.56%

Cause is most prevalent in: New York (117.92 deaths per 100,000 people)

The most common cause of death in the United States, atherosclerotic heart disease results from a wide array of factors, many of which become increasingly difficult to manage with increased age. While smoking, high cholesterol, and a diet lacking sufficient nutrition can all contribute to the development of atherosclerosis, it can also be onset simply by a , which is increasingly harder to avoid as one's bones become more fragile and as mobility decreases.